A fast-responsive turn on fluorescent probe for detecting endogenous hydroxyl radicals based on a hybrid carbazole-cyanine platform

作者：Wang, Jian-Yong; Liu, Zhan-Rong; Ren, Mingguang; Kong, Xiuqi; Liu, Keyin; Deng, Beibei; Lin, Weiying^*

来源：Sensors and Actuators B: Chemical , 2016, 236: 60-66.

DOI：10.1016/j.snb.2016.04.163

• Fluorescent probe
• Hydroxyl radicals
• Living cells

A novel turn on fluorescent probe based on a hybrid carbazole-cyanine platform was designed and synthesized for detecting hydroxyl radicals. The probe had exhibited ideal properties including fast response( 0.5min), good selectivity, and low cytotoxicity. Almost 60-fold fluorescence enhancement was obtained in the presence of (OH)-O-center dot in solution. The novel fluorescent probe could be employed to image endogenous hydroxyl radicals in living cells.

• 出版日期2016-11-29
• 单位济南大学