Association Between IL-6-174G/C Polymorphism and Risk of Multiple Sclerosis: A Meta-Analysis

作者：Hu, Shan; Chen, Ying; Sun, Xu-Dong; Li, Fu-Jin; Shu, Qin-Fen; Liu, Xiao-Li; Jiang, Shou-Feng^*

来源：Genetic Testing and Molecular Biomarkers, 2014, 18(2): 127-130.

DOI：10.1089/gtmb.2013.0387

• IL-6
• CYTOKINES
• GENE
• EXPRESSION
• TNF

Objective: Interleukin-6 (IL-6) is a pleiotropic cytokine and important mediator of many inflammatory processes, which might affect susceptibility to multiple sclerosis (MS). The aim of this study was to assess the effect of IL-6-174G/C polymorphism on the risk of MS using a meta-analysis.Materials and Methods: The Pubmed, ISI Web of Science, Wanfang, VIP, and China National Knowledge Infrastructure databases were screened and six studies were included in the meta-analysis. Pooled odds ratios (ORs) with corresponding 95% confidence intervals (CI) were calculated to evaluate the association between the IL-6-174G/C polymorphism and risk of MS.Results: No significant association between the IL-6-174G/C polymorphism and risk of MS was observed in overall analyses. With stratification according to ethnicity, we found that carriers with the IL-6-174CC genotype had a 1.87-fold increased risk for the development of MS in Asians (recessive model: OR=1.87, 95% CI, 1.08-3.24), but not in Caucasians.Conclusion: This meta-analysis provides evidence that the IL-6-174G/C polymorphism may be a risk factor for the development of MS in Asians. Further association studies with a larger sample size are required to confirm the result in different populations.

• 出版日期2014-2-1
• 单位浙江大学; 浙江医院