A joint detection of CEA and CA-50 levels in saliva and serum of patients with tumors in oral region and salivary gland

作者：He, Hong; Chen, Guanfu^*; Zhou, Liang; Liu, Yanmin

来源：Journal of Cancer Research and Clinical Oncology, 2009, 135(10): 1315-1321.

DOI：10.1007/s00432-009-0572-x

• Saliva
• Carcinoembryonic antigen
• Carcinoma associated antigen CA-50
• Oral tumor

To detect the levels of carcinoembryonic antigen (CEA) and carcinoma associated antigen CA-50 in the patients with oral or salivary malignant tumors. @@@ The concentrations of salivary CEA and CA-50 were assayed in 80 patients of oral and salivary malignant tumors, 40 patients of benign tumors and 80 health controls. In 80 patients with malignant tumors, serum CEA and CA-50 were also assayed by enzyme-linked immunoabsorbent assay and immunoradiometric analysis, respectively. @@@ Salivary CEA and CA-50 levels were significantly higher in malignant tumors than in benign tumors and in health controls, respectively (P < 0.001). Only 7 cases and 3 cases of 80 patients with malignant tumors were found having increased serum CEA and CA-50 levels, respectively. @@@ The measurement of CEA and CA-50 levels in saliva were more sensitive than in serum. This may be more useful as prognostic indicators in early diagnosis of oral and salivary malignant tumors.

• 出版日期2009-10
• 单位浙江大学