Association of periodontitis with GSTMI/GSTTI-null variants - A pilot study

作者：Concolino Paola; Cecchetti Francesco; D'Autilla Caterina; SantonoCito Concetta; Di Stasio Enrico; Zuppi Cecilia; Arcuri Claudio; Deli Giorgio; Giardina Bruno; Capoluongo Ettore^*; Arneglio Franco

来源：Clinical Biochemistry, 2007, 40(13-14): 939-945.

DOI：10.1016/j.clinbiochem.2007.04.012

• GSTTI
• GSTMI
• periodontitis

Objectives: To analyze a possible association between glutathione-S-transferase T1 (GSTM1) and/or glutathione-S-transferase M1 (GSTM1) polymorphisms and chronic or aggressive forms of periodontitis in a Caucasian ethnic group.
Design and methods: Sixty-nine chronic, 14 aggressive periodontitis and 61 controls, deeply analyzed from a clinical point of view, were studied for their GSTM1 and GSTT1 polymorphisms by allefic specific PCR techniques. As a second control group, 64 blood donors were also included.
Results: A significant association was found between GSTM1-null genotype and both chronic and aggressive periodontitis. The aggressive forms were associated with the double null GSTM1 and GSTT1 combination. These results were independent of the patients' age, gender, hygienic habits and smoke (evaluated as tobacco smoking yes/no, cigarettes/day and pack years) as confirmed by multivariate logistic regression analysis.
Conclusions: The GSTM1-null variant is statistically associated with the two forms of periodontitis, while the aggressive one also presents a second null variant: GSTT1.

• 出版日期2007-9
• 单位中国人民解放军空军预警学院