Wondonin, a novel compound, inhibits hypoxia-induced angiogenesis through hypoxia-inducible factor 1 alpha

作者：Jun Hyoung Oh; Kim Younghwa; Kwon Yoo Wook; Hong Soon Sun; Kim Kyu Won; Shin Jongheon; Kim Tae Yoon^*

来源：FEBS Letters, 2007, 581(25): 4977-4982.

DOI：10.1016/j.febslet.2007.09.034

• wondonin
• HIF-1 alpha
• VEGF
• anti-angiogenic activity
• angiogenesis

Hypoxia regulates a variety of transcription factors including HIT-1, which has been considered a target for anti-angiogenic therapy. While searching for a novel anti-angiogenic agent that would inhibit HIF-1 activity, we identified wondonin, a new his imidazole purified from an association of the sponges Poecillastra wondoenis Wondonin significantly decreased hypoxia-induced HIF-1 alpha protein and VEGF expression and inhibited angiogenesis in vitro and in vivo. Furthermore, wondonin down-regulated HIF-1 alpha protein through the increased interaction with the pVHL in immortalized human keratinocyte cell line. Wondonin also decreased the immunoreactivities of CD31 and VEGF in epidermal hyperplasia in mice. Taken together, these results suggested that wondonin had the potential to become the anti-angiogenic therapeutic agent to target HIF-1 alpha.

• 出版日期2007-10-16
• 单位河北医科大学