Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions

作者：Lafourcade Mathieu; Larrieu Thomas; Mato Susana; Duffaud Anais; Sepers Marja; Matias Isabelle; De Smedt Peyrusse Veronique; Labrousse Virginie F; Bretillon Lionel; Matute Carlos; Rodriguez Puertas Rafael; Laye Sophie^*; Manzoni Olivier J

来源：Nature Neuroscience, 2011, 14(3): 345-350.

DOI：10.1038/nn.2736

The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3-deficient mice, presynaptic cannabinoid CB(1) receptors (CB(1)Rs) normally responding to endocannabinoids were uncoupled from their effector G(i/o) proteins. Finally, the dietary-induced reduction of CB(1)R functions in mood-controlling structures was associated with impaired emotional behavior. These findings identify a plausible synaptic substrate for the behavioral alterations caused by the n-3 PUFAs deficiency that is often observed in western diets.

• 出版日期2011-3