Asymmetric Total Synthesis of Clavolonine

作者：Nakahara Kenji; Hirano Kie; Maehata Ryota; Kita Yasuyuki; Fujioka Hiromichi^*

来源：Organic Letters, 2011, 13(8): 2015-2017.

DOI：10.1021/ol200376z

The asymmetric total synthesis of clavolonine (1) has been achieved based on chiral auxiliary multiple-use methodology. Our synthetic route features stereoselective transformations on the cyclohexane ring utilizing the steric environment of the chiral auxiliary and an intramolecular Mannich reaction to construct the fused ring system.

• 出版日期2011-4-15