Advances in Genetic Studies of Attention-Deficit/Hyperactivity Disorder

作者：Smith Alicia K; Mick Eric; Faraone Stephen V^*

来源：Current Psychiatry Reports, 2009, 11(2): 143-148.

DOI：10.1007/s11920-009-0022-0

Attention-deficit/hyperactivity disorder (ADHD) is among the most common childhood-onset psychiatric disorders. Although family, twin, and adoption studies demonstrate that ADHD is a highly heritable condition, studies also suggest that genetic architecture is complex, prompting the use of more advanced methodologies such as genome-wide linkage and association studies. Although such studies are theoretically compelling, replication of these results has been inconsistent. Meta-analyses have produced more reliable results, but the associations identified to date account for only a small percentage of the genetic component of ADHD. Approaches such as neuroimaging genetics and epigenetic studies are being explored to probe further the etiologic complexity of this disorder.

• 出版日期2009-4