Apolipoprotein E epsilon 2 allele and low serum cholesterol as risk factors for gastric cancer in a Chinese Han population

作者：Kang, Ranran; Li, Ping; Wang, Tingting; Li, Xinxiu; Wei, Zichen; Zhang, Zhenlian; Zhong, Li; Cao, Longlong; Heckman, Michael G.; Zhang, Yun-Wu; Xu, Huaxi; Huang, Changming^*; Bu, Guojun^*; Chen, Xiao-Fen^*

来源：Scientific Reports, 2016, 6(1): 19930.

DOI：10.1038/srep19930

• E POLYMORPHISM
• COLORECTAL-CANCER
• BREAST-CANCER
• CELL-PROLIFERATION
• ALZHEIMERS-DISEASE
• TRANSPORT PROTEIN
• APOE POLYMORPHISM
• GENE-EXPRESSION
• SERIAL ANALYSIS
• E GENOTYPES

Apolipoprotein E (apoE) mediates lipid metabolism both in peripheral and in the brain. The human APOE gene has three polymorphic alleles that influence the risk for various types of cancer and neurodegenerative diseases. A potential association between APOE allele and the risk for gastric cancer has been implicated, but the specific allele involved and potential associations with the subtype and the grade of cancer malignancy need further clarification. We screened the APOE genotype in 550 gastric cancer patients and 550 non-cancer control individuals and found that the presence of the APOE epsilon 2 and lower serum total cholesterol are associated with an increased risk for gastric cancer (all P <= 0.0005). Interestingly, APOE epsilon 2 is also correlated with increased risk for both intestinal and diffuse histotypes but not with TN classification or stage in gastric cancer patients, suggesting that APOE polymorphic alleles are associated with the risk of development but unlikely the progression of gastric cancer. Since epsilon 2 carriers have lower levels of serum total cholesterol than non-epsilon 2 carriers, our findings suggest that the increased risk for gastric cancer by APOE epsilon 2 allele might be mediated through lowered serum total cholesterol levels.

• 出版日期2016-1-28
• 单位福建医科大学; 厦门大学