Ultrasound assisted one-pot synthesis of benzo-fused indole-4,9-dinones from 1,4-naphthoquinone and alpha-aminoacetals

作者：Luu Quang H; Guerra Jorge D; Castaneda Cecilio M; Martinez Manuel A; Saunders Jong; Garcia Benjamin A; Gonzales Brenda V; Aidunuthula Anushritha R; Mito Shizue^*

来源：Tetrahedron Letters, 2016, 57(21): 2253-2256.

DOI：10.1016/j.tetlet.2016.04.031

• p-Indolequinone
• Cyclization
• One-pot reaction
• Ultrasound-assisted
• Heterocycles

A one-pot synthesis of benzo[f]indole-4,9-diones from 1,4-naphthoquinone with alpha-aminoacetals has been developed. This method provides a straightforward synthesis of benzo[f]indole-4,9-diones via intramolecular nucleophilic attack of aminoquinones to aldehydes under mild reaction conditions. The detailed mechanism was also investigated.

• 出版日期2016-5-25