Depot GnRH-agonist trigger for breast-cancer patient undergoing ovarian stimulation resulted in mature oocytes for cryopreservation: a case report

作者：Cavagna Mario^*; Dzik Artur

来源：Reproductive BioMedicine Online, 2011, 22(3): 317-319.

DOI：10.1016/j.rbmo.2010.11.015

• fertility preservation
• GnRH agonist
• GnRH antagonist
• oocyte cryopreservation
• ovarian stimulation

This report describes the case of a 27-year-old woman with breast cancer who underwent ovarian stimulation for fertility preservation with recombinant FSH in conjunction with a gonadotrophin-releasing hormone (GnRH) antagonist and an aromatase inhibitor from the beginning of the treatment. A 3.75-mg triptorelin depot formulation was given intramuscularly when the follicular diameter of three follicles reached >= 20 mm and a total of 13 follicles reached >= 15 mm. Oocyte retrieval was scheduled for 36 h later and 10 mature oocytes were collected and vitrified. This case report demonstrates that a depot GnRH-agonist trigger effectively leads to mature oocyte retrieval, with the advantage of initiating ovarian suppression for the purpose of fertility preservation during adjuvant chemotherapy in breast-cancer patients.

• 出版日期2011-3