Fas ligand (FasL) and Fas-associated death domain (FADD) were elevated in decidual stromal and glandular epithelial cells in spontaneous early miscarriage women

作者：Wang, Li-qin; Zhao, Yue; Yu, Xue-wen^*; Zhang, Yong-ai

来源：African Journal of Microbiology Research, 2012, 6(10): 2252-2257.

DOI：10.5897/AJMR11.629

• Fas ligand
• Fas-associated death domain and spontaneous early miscarriage

Examine the Fas ligand (FasL) and Fas-associated death domain (FADD) expression of decidual tissues in first trimester human pregnancies and spontaneous early miscarriage (SEM), in order to find a possible involvement in the pathogenic etiology of SEM. In this study, we included 35 women with SEM and 35 women with healthy pregnancy. The protein expressions of FasL and FADD of decidual tissues were examined using immunohistochemistry and immunofluoresence. The decidual stromal cells, glandular epithelial cells, and vessel endothelial cells in the first trimester pregnancies expressed FasL and FADD proteins. SEM was accompanied by increased FasL and FADD protein expression in decidual stromal cells and glandular epithelial cells, especially women with at least one miscarriage prior (P < 0.01). Stronger FasL and FADD staining in the decidual stromal cells and glandular epithelial cells suggest increased expression of FasL and FADD in SEM. These data suggest that there is a different regulation of the FasL system in three types of decidual cells in early human pregnancies. Disturbance in expression of FasL and FADD in decidual of early pregnancies seems to be associated with SEM.

• 出版日期2012-3-16
• 单位西安交通大学; 西安医学院