Microarc oxidized TiO2 based ceramic coatings combined with cefazolin sodium/chitosan composited drug film on porous titanium for biomedical applications

作者：Wei, Daqing^*; Zhou, Rui; Cheng, Su; Feng, Wei; Li, Baoqiang; Wang, Yaming; Jia, Dechang; Zhou, Yu; Guo, Haifeng

来源：Materials Science & Engineering C-Materials for Biological Applications, 2013, 33(7): 4118-4125.

DOI：10.1016/j.msec.2013.05.053

• Microarc oxidation
• Porous titanium
• Mechanical properties
• Cefazolin sodium/chitosan
• Kinetics

Porous titanium was prepared by pressureless sintering of titanium beads with diameters of 100, 200, 400 and 600 mu m. The results indicated that the mechanical properties of porous titanium changed significantly with different bead diameters. Plastic deformations such as necking phenomenon and dimple structure were observed on the fracture surface of porous titanium sintered by beads with diameter of 100 gm. However, it was difficult to find this phenomenon on the porous titanium with a titanium bead diameter of 600 mu m. The microarc oxidized coatings were deposited on its surface to improve the bioactivity of porous titanium. Furthermore, the cefazolin sodium/chitosan composited films were fabricated on the microarc oxidized coatings for overcoming the inflammation due to implantation, showing good slow-release ability by addition of chitosan. And the release kinetic process of cefazolin sodium in composited films could be possibly fitted by a polynomial model.

• 出版日期2013-10-1
• 单位哈尔滨学院; 哈尔滨工业大学