Mutant IDH1: An immunotherapeutic target in tumors

作者：Schumacher Theresa; Bunse Lukas; Wick Wolfgang; Platten Michael^*

来源：OncoImmunology, 2014, 3(12): e974392.

DOI：10.4161/2162402X.2014.974392

• IDH1 mutation
• glioma
• cancer immunotherapy
• MHC-humanized mice
• mutation-specific CD4(+) T-cells
• MHC class II epitope

The discovery of driver mutations in cancers has raised interest in their suitability as immunotherapeutic targets. A recent study demonstrates that a point mutation in isocitrate dehydrogenase 1 (IDH1R132H), expressed in gliomas and other tumors, is presented on human MHC class II and induces a mutation-specific CD4(+) antitumor T cell response in patients and a syngeneic tumor model in MHC-humanized mice.

• 出版日期2014-12