MEMORY IMPAIRMENT INDUCED BY BRAIN IRON OVERLOAD IS ACCOMPANIED BY REDUCED H3K9 ACETYLATION AND AMELIORATED BY SODIUM BUTYRATE

作者：da Silva P F; Garcia V A; Dornelles A da S; da Silva V K; Maurmann N; Portal B C D; Ferreira R D P; Piazza F C; Roesler R; Schroeder N^*

来源：Neuroscience, 2012, 200: 42-49.

DOI：10.1016/j.neuroscience.2011.10.038

• sodium butyrate
• object recognition
• inhibitory avoidance
• neurodegeneration
• iron
• histone acetylation

Iron accumulation in the brain has been associated to the pathogenesis of neurodegenerative disorders. We have previously demonstrated that iron overload in the neonatal period results in severe and persistent memory deficits in adult rats. Alterations in histone acetylation have been associated with memory deficits in models of neurological disorders. Here we examine histone acetylation in the brain and the effects of the histone deacetylase inhibitor (HDACi) sodium butyrate (NaB) on memory in the neonatal iron overload model in rats. Rats received vehicle or 30.0-mg/kg Fe(+2) orally at postnatal days 12-14. When animals reached adulthood, they were given training in either novel object recognition or inhibitory avoidance. Histone acetylation in the dorsal hippocampus and the effects of NaB were examined in separate sets of rats. Iron overload led to a reduction in H3 lysine 9 acetylation in the hippocampus, without affecting the acetylation of other H3 and H4 lysine residues. A single systemic injection of NaB (1.2 g/kg) immediately after training ameliorated iron-induced memory impairments. The results suggest that a reduction in H3K9 acetylation might play a role in iron-induced memory impairment and support the view that HDACis can rescue memory dysfunction in models of brain disorders.

• 出版日期2012-1-3