A Phase II Trial of Fludarabine/Melphalan 100 Conditioning Therapy Followed by Allogeneic Hematopoietic Cell Transplantation for Patients With Lymphoma

作者：Lee Jung Hee; Lee Je Hwan; Kim Dae Young; Seol Miee; Lee Young Shin; Kang Young Ah; Jeon Mijin; Lee Kyoo Hyung

来源：Clinical Lymphoma Myeloma & Leukemia, 2015, 15(11): 655-663.

DOI：10.1016/j.clml.2015.08.087

• Allogeneic
• HOT
• Lymphoma
• Melphalan
• Non-myeloablative

In our phase II trial, we investigated a conditioning regimen of fludarabine and melphalan 100 mg/m(2) for allogeneic hematopoietic cell transplantation for lymphoma. The 5-year overall survival rate was 40.4%, and the nonrelapse mortality rate was 21.6%. Patients with severe chronic graft-versus-host disease (GVHD) had greater overall survival than those with no, mild, or moderate chronic GVHD. Conditioning therapy with a lower dose of melphalan, combined with fludarabine, appears to be promising for allogeneic transplantation for lymphoma.
Background: Conditioning therapy with fludarabine and melphalan 140 mg/m2 has been widely used before allogeneic hematopoietic cell transplantation (HOT) for lymphoma. A lower dose of melphalan might result in lower mortality and morbidity without compromising engrattment. Patients and Methods: In our phase II trial, we investigated a conditioning regimen of fludarabine (30 mg/m(2)/day for 5 days on days 6 to 2) and melphalan (100 mg/m2 on day 2). Antithymocyte globulin was added to fludarabine and melphalan for unrelated or mismatched familial donor HOT. The present study included 26 patients with lymphoma (B-cell in 10, T-cell in 11, and natural killer/T-cell lymphoma in 2). Results: An objective tumor response after HOT was observed in 18 patients (75.0%; complete in 14 and partial in 4). Acute and chronic graft-versus-host disease (GVHD) occurred in 23.1% and 55.0% of the assessable patients, respectively. The 5-year overall survival, nonrelapse mortality, progression-free survival, and event-free survival rate was 40.4%, 21.6%, 39.2%, and 30.8%, respectively. Donor lymphocyte infusions were given to 3 patients who had developed a relapse or progression after HOT, and 2 of whom had a showed partial response. Patients with severe chronic GVHD had greater overall survival than those with no, mild, or moderate chronic GVHD. Conclusion: Conditioning therapy with a lower dose of melphalan, combined with fludarabine, appears to be promising in allogeneic HCT for lymphoma.

• 出版日期2015-11