Zwitterionic betaine-cholesterol system: Effects of sonication duration and aging on vesicles stability

作者：Alenaizi R^*; Radiman S; Rahman I Abdul; Mohamed F

来源：Colloids and Surfaces A: Physicochemical and Engineering Aspects , 2015, 482: 662-669.

DOI：10.1016/j.colsurfa.2015.07.009

• Vesicles
• Zwitterionic surfactant
• Cholesterol
• Ternary phase diagram
• Dynamic light scattering
• Negative-staining TEM

Nanovesicle structures are an important class of nanoparticle self-assembly offering potential drug delivery applications depending on vesicle shape, size, and stability. The influence of the sonication time and aging effects on size distribution and stability of the vesicles formed in aqueous mixtures of the Zwitterionic surfactant betaine and cholesterol was studied using ternary phase diagrams, negative-staining transmission electron microscopy, and dynamic light scattering. The vast majority of our results reveal assembly of vesicles displaying spherical morphology with diameters varying between 42 and 179 nm during the 42 days of aging period at room temperature. Furthermore, analysis of vesicle structure and conformation following sonication indicate conservation of structural stability without using any stabilizing additives.

• 出版日期2015-10-5