ANTIHYPERLIPIDEMIC EFFICACY OF FLAVONOID-RICH FRACTION FROM SPERMACOCE HISPIDA SEED ON HIGH-FAT-DIET FED RATS: A DOSE-DEPENDENT STUDY

作者：Kaviarasan K; Mohankumar R; Narasimhan S; Viswanathan P; Pugalendi K V^*

来源：Journal of Food Biochemistry, 2011, 35(6): 1627-1636.

DOI：10.1111/j.1745-4514.2010.00482.x

The aim of the experiment was to investigate the antihyperlipidemic effect of Spermacoce hispida seed-flavonoid-rich fraction by a dose-dependent study. Lipid and lipoprotein profiles and the activities of lipid metabolizing enzymes were measured in plasma and tissues of high-fat-diet fed and control rats. The levels of plasma and tissue total cholesterol, triglycerides and plasma phospholipids, free fatty acids, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol were reduced significantly, while high-density lipoprotein cholesterol significantly elevated in S. hispida flavonoid-rich fraction (S-Frf) fed groups when compared to high-fat-diet fed group. HMG CoA reductase activity significantly decreased while the lipoprotein lipase and lecithin cholesterolacyl transferase activities were elevated in rats fed with flavonoid-rich fraction. Among the doses, 40 mg dose showed maximum effect. High performance liquid chromatography analysis of flavonoid-rich fraction indicates that the antihyperlipidemic activity is due to the presence of ursolic acid, quercetin, isorhamnetin and hesperetin.

• 出版日期2011-12