Sixty-Hertz Stimulation Improves Bradykinesia and Amplifies Subthalamic Low-Frequency Oscillations

作者：Blumenfeld Zack; Koop Mandy Miller; Prieto Thomas E; Shreve Lauren A; Velisar Anca; Quinn Emma J; Trager Megan H; Bronte Stewart Helen

来源：Movement Disorders, 2017, 32(1): 80-88.

DOI：10.1002/mds.26837

• deep brain stimulation
• Parkinson's disease
• beta oscillations
• low frequency
• subthalamic nucleus

Background: The objective of this study was to investigate the hypothesis that attenuation of subthalamic nucleus (STN) alpha-/beta-band oscillations is causal to improvement in bradykinesia.
Methods: STN local field potentials from a sensing neurostimulator (Activa VR PC1S; Medtronic, Inc.) and kinematics from wearable sensors were recorded simultaneously during 60-and 140-Hz deep brain stimulation (DBS) in 9 freely moving PD subjects (15 STNs) performing repetitive wrist flexion-extension. Kinematics were recorded during 20-Hz DBS in a subgroup.
Results: Both 60-and 140-Hz DBS improved the angular velocity and frequency of movement (P=0.002 and P=0.029, respectively, for 60 Hz; P < 0.001 and P < 0.001, respectively, for 140 Hz), but 60-Hz DBS did not attenuate beta-band power (13-30 Hz). In fact, 60-Hz DBS amplified alpha/low-beta (11-15 Hz, P=0.007) and attenuated high-beta power (19-27 Hz, P < 0.001), whereas 140-Hz DBS broadly attenuated beta power (15-30 Hz, P < 0.001). Only 60-Hz DBS improved the regularity of angular range (P=0.046) and 20-Hz DBS did not worsen bradykinesia. There was no correlation between beta-power modulation and bradykinesia.
Conclusions: These novel results obtained from freely moving PD subjects demonstrated that both 140and 60-Hz DBS improved bradykinesia and attenuated high beta oscillations; however, 60-Hz DBS amplified a subband of alpha/low-beta oscillations, and DBS at a beta-band frequency did not worsen bradykinesia. Based

• 出版日期2017-1