Antimicrobial sesquiterpenes from the Chinese medicinal plant, Chloranthus angustifolius

作者：Yang, Xinzhou; Wang, Chao; Yang, Jing; Wan, Dingrong; Lin, Qinxiong; Yang, Guangzhong; Mei, Zhinan^*; Feng, Yunjiang

来源：Tetrahedron Letters, 2014, 55(41): 5632-5634.

DOI：10.1016/j.tetlet.2014.08.052

• Chloranthus angustifolius
• Eudesmane sesquiterpenes
• Antimicrobial
• Traditional Chinese medicine

Two new eudesmane-type sesquiterpenes, 9 alpha-hydroxycurcolonol (1) and 3 alpha-hydroxy-4-deoxy-5-dehydrocurcolonol (2), along with nine known sesquiterpenes (3-11), were isolated from the roots of Chloranthus angustifolius. The antimicrobial activities of compounds 1-11 were evaluated against five bacteria and six fungal strains. Compounds 6-11 showed potent activities against Candida albicans with MIC values ranging from 4 to 8 mu g/mL. The structures of the two new compounds 1 and 2 were established by a detailed analysis of their NMR and mass spectroscopic data.

• 出版日期2014-10-8
• 单位中南民族大学