科研之友
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摘要
Background Central nervous system histaminergic tone is thought to play a role in appetite regulation In animal models histamine receptor 1 (HRH1) agonists and histamine receptor 3 (HRH3) an tagonists decrease food intake Objective The objective of this study was to examine the acute effects of betahistine hydrochloride (an HRH1 agonist and HRH3 antagonist) on food intakes and appetites Design The study was a proof of concept rindomized double blinded placebo controlled dose ranging study performed to exam me the effects of betahistine in women with class I or II obesity [body mass Index (BMI in kg/m(2)) of 30-39 991 After a 24 h placebo run in period subjects received a placebo (n = 19) or 48 (n = 19) 96 (n = 17) or 144 (n = 21) mg betahistine/d for 24 h Treatment was followed by a buffet test meal to assess energy intake Hunger satiety and desire to eat were measured after consuming the meal by using visual analog scales Data were analyzed by using regression models with the assumption that there would be an in creasing effect of betahistine doses Analyses were adjusted for age log fat and lean mass food preferences and intake during a buffet test meal obtained during the placebo run in period Results Of the 79 obese women (mean +/- SD age 42 +/- 11 y BMI 35 +/- 3) enrolled in the study 76 women completed the study The betahistine dose did not significantly change intakes from those observed during the run in period of the buffet test meal (P = 0 78) Hunger fullness and desire to eat (all P > 0 62) similarly showed no differences according to the betahistine close Conclusions Betahistine did not produce an effect on food intakes or appetites More potent histaminergic modulators may he required to elucidate the possible role of histaminergic pathways in human obesity This trial was registered at clinicaltrials gov as NCT00459992 Am J Clin Nutr 2010 92 1290-7
- 出版日期2010-12
