Development of a new Papillon 50 (TM) machine with dedicated applicators used for 50 kV X-ray radiotherapy of rectal and skin cancers

作者：Gerard J P^*; Marcie S; Croce O; Hachem S; Trimaud R; Bordy J M; Denoziere M; Courdi A; Benezery K; Levi J M Hannoun; Barbet N

来源：IRBM, 2012, 33(2): 109-116.

DOI：10.1016/j.irbm.2012.01.003

Objective. - Contact X-Ray 50 kV (CXRT) has proven its efficiency to treat rectum and skin cancers. The goal of this technological research was to design and produce a new CXRT machine with dedicated applicators to replace the Philips unit not any more manufactured. %26lt;br%26gt;Materials and methods. - The P50 was assembled in UK and the characteristics of the machine were evaluated with spectrometers, ions chambers, Gafchromic films and Monte Carlo code. The applicators were designed and manufactured in Nice. Dosimetric data were measured for each applicator. Validated protocols were used to treat patients. %26lt;br%26gt;Results. - Between September 2009 and November 2011, the performances of the P50 was judged satisfactory with a dose rate close to 15 Gy/min depending on the applicator. The dose distribution was according to objectives. Clinical results achieved in 62 patients treated in centre Antoine-Lacassagne for rectum, skin or eyelid cancers confirmed the efficiency and good tolerance of CXRT. Similar results in rectal cancer were observed in Clatterbridge with 120 rectal cancers treated with P50. %26lt;br%26gt;Discussion %26lt;br%26gt;These results are encouraging and should contribute to the international dissemination of CXRT. New machine (Papillon Plus) should be designed and produced for intraoperative irradiation and treatment of vaginal vault. %26lt;br%26gt;Conclusion. - This experience of research and development well structured within the frame of TecSan project should be encouraged further to facilitate technological innovation in the field of radiotherapy.

• 出版日期2012-4