Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy

作者：Ichihara Sahoko^*; Yamada Yoshiji; Ichihara Gaku; Kanazawa Hiroaki; Hashimoto Katsunori; Kato Yosuke; Matsushita Aya; Oikawa Shinji; Yokota Mitsuhiro; Iwase Mitsunori

来源：Biochemical and Biophysical Research Communications, 2006, 350(1): 105-113.

DOI：10.1016/j.bbrc.2006.09.026

• adrenoceptors
• cardiomyopathy
• cytokines
• heart failure
• NADPH oxidase

Oxidative stress is an important susceptibility factor for dilated cardiomyopathy. We have investigated the effects of bisoprolol, a beta(1)-selective adrenoceptor blocker, on oxidative stress and the development of cardiac dysfunction in a model of dilated cardiomyopathy. Male TO-2 and control hamsters at 8 weeks of age were treated with bisoprolol (5 mg/kg per day) or vehicle for 4 weeks. Treatment with bisoprolol prevented the progression of cardiac dysfunction in TO-2 hamsters. This drug did not affect the increase in NADPH oxidase activity but prevented the reduction in activity and expression of mitochondrial manganese-dependent superoxide dismutase as well as the increases in the concentrations of interleukin-1 beta and tumor necrosis factor-alpha in the left ventricle of TO-2 hamsters. Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle.

• 出版日期2006-11-10