An efficient synthesis of polysubstituted 1,3-enynes from (E)-beta-iodovinyl sulfones and terminal alkynes

作者:Gu Xiao Xia; Xie Mei Hua*; Zhao Xin Yang; Sun Ying; Zhang Wei; Xie Fa Dong; Wang Shao Wu
来源:Chinese Journal of Chemistry, 2008, 26(9): 1625-1629.
DOI:10.1002/cjoc.200890293

摘要

Sulfonyl-substituted 1,3-enynes were synthesized in moderate to high yields by Sonogashira coupling reaction of (E)-beta-iodovinyl sulfones with terminal alkynes. The sulfonyl group was further transformed to various substitutents by desulfonylation coupling with Grignard reagents in the presence of NiCl(2)(PPh(3))(2).