Wang resin-supported sulfonic acid-catalyzed multicomponent reaction in water leading to 4-oxo-4,5,6,7-tetrahydroindole derivatives

作者：Dinne Naresh Kumar Reddy; Mekala Ramamohan; Reddy S Pulla; Siva Ganesh Yaddanapudi Sesha; Bannoath Chandrasekhar Kothapalli

来源：Synthetic Communications, 2018, 48(13): 1649-1656.

DOI：10.1080/00397911.2018.1458240

• Dimedone
• multicomponent reactions (MCR)
• phenacyl bromide
• tetrahydro indoles
• Wong-OSO3H

A greener approach for the synthesis of 4-oxo-4,5,6,7-tetrahydro indole derivatives has been achieved through Wang-OSO3H-mediated three-component reaction involving dimedone, phenacyl bromide, and primary amine in water. A variety of indole derivatives were prepared using this operationally simple and straight forward methodology in acceptable yields.
[GRAPHICS]
.

• 出版日期2018