An efficient access to N-tert-butanesulfinyl aldimines in water: Application to one-pot synthesis of homoallylic amines, (+)-crispine A and (-)-coniine

作者：Sun, Kai; Yuan, Bin-Hua; Hu, Yong^*; Sun, Xing-Wen^*; Lin, Guo-Qiang

来源：Journal of Saudi Chemical Society, 2018, 22(6): 654-664.

DOI：10.1016/j.jscs.2017.11.005

• N-tert-Butanesulfinyl aldimines
• Chiral homoallylic amines
• Aqueous reaction
• (+)-Crispine A
• (-)-Coniine

An Efficient method for the syntheses of N-tert-butanesulfinyl aldimines in water was developed using Amberlyst-15 as catalyst. Subsequently, chiral homoallylic amines were synthesized in one pot from aldehydes by combining with In-promoted allylation in aqueous media. The total syntheses of (+)-Crispine A and (-)-Coniine were conducted to demonstrate the utility of this one-pot approach.

• 出版日期2018-9
• 单位上海交通大学; 复旦大学