Association study of interleukin-1 family, interleukin-6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

作者：Holla Lydie Izakovicova^*; Valova Simona; Linhartova Petra Borilova; Bartova Jirina; Petanova Jitka; Kuklinek Pavel; Fassmann Antonin

来源：Journal of Oral Pathology & Medicine, 2017, 46(10): 1030-1035.

DOI：10.1111/jop.12594

• aphthous stomatitis
• case-control study
• gene polymorphism
• interleukin-1
• interleukin-6

BackgroundRecurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-6 (IL-6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL-1 cytokine family, IL-6 or its receptor and RAS in the Czech population.
MethodsA total of 248 subjects, 184 healthy controls, and 64 patients with RAS were genotyped for IL-1A-889C>T, IL-1B-511C>T, IL-1B+3953C>T, IL-1RN86bp variable number of tandem repeats (VNTRs) in intron 2, IL-6-597G>A, IL-6-572G>C, IL-6-174G>C, and IL-6R+48992A>C by polymerase chain reaction (PCR) methods.
ResultsNo significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>.05). In addition, complex analysis also revealed similar IL-1 or IL-6 haplotype frequencies between both groups (P>.05).
ConclusionsIn conclusion, IL-1 and IL-6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.

• 出版日期2017-11