Development of a palladium-catalyzed decarboxylative cross-coupling of (2-azaaryl)carboxylates with aryl halides

作者：Haley Christopher K; Gilmore Christopher D; Stoltz Brian M^*

来源：Tetrahedron, 2013, 69(27-28): 5732-5736.

DOI：10.1016/j.tet.2013.03.085

• Decarboxylative cross-coupling
• (2-Azaaryl)carboxylates
• Palladium
• Copper

A catalytic method for the decarboxylative coupling of 2-(azaaryl)carboxylates with aryl halides is described. The decarboxylative cross-coupling presented is mediated by a system catalytic in both palladium and copper without requiring stoichiometric amounts of organometallic reagents or organoboronic acids. This method circumvents additional synthetic steps required to prepare 2-azaatyl organometallics and organoborates as nucleophilic coupling partners, which are prone to protodemetallation and protodeborylation and produce potentially toxic byproducts.

• 出版日期2013-7-8