Differences in Nutritional Status Between Very Mild Alzheimer's Disease Patients and Healthy Controls

作者：Rikkert Marcel G M Olde^*; Verhey Frans R; Sijben John W C; Bouwman Femke H; Dautzenberg Paul L J; Lansink Mirian; Sipers Walther M W; van Asselt Dieneke Z B; van Hees Anneke M J; Stevens Martijn; Vellas Bruno; Scheltens Philip

来源：Journal of Alzheimer's Disease, 2014, 41(1): 261-271.

DOI：10.3233/JAD-131892

• Alzheimer's disease
• fatty acids
• healthy volunteers
• micronutrients
• nutritional status
• protein-energy malnutrition

Background: Studies on the systemic availability of nutrients and nutritional status in Alzheimer's disease (AD) are widely available, but the majority included patients in a moderate stage of AD.
Objective: This study compares the nutritional status between mild AD outpatients and healthy controls.
Methods: A subgroup of Dutch drug-naive patients with mild AD (Mini-Mental State Examination (MMSE) >= 20) from the Souvenir II randomized controlled study (NTR1975) and a group of Dutch healthy controls were included. Nutritional status was assessed by measuring levels of several nutrients, conducting the Mini Nutritional Assessment (MNA (R)) questionnaire and through anthropometric measures.
Results: In total, data of 93 healthy cognitively intact controls (MMSE 29.0 [23.0-30.0]) and 79 very mild AD patients (MMSE = 25.0 [20.0-30.0]) were included. Plasma selenium (p < 0.001) and uridine (p = 0.046) levels were significantly lower in AD patients, with a similar trend for plasma vitamin D (p = 0.094) levels. In addition, the fatty acid profile in erythrocyte membranes was different between groups for several fatty acids. Mean MNA screening score was significantly lower in AD patients (p = 0.008), but not indicative of malnutrition risk. No significant differences were observed for other micronutrient or anthropometric parameters.
Conclusion: In non-malnourished patients with very mild AD, lower levels of some micronutrients, a different fatty acid profile in erythrocyte membranes and a slightly but significantly lower MNA screening score were observed. This suggests that subtle differences in nutrient status are present already in a very early stage of AD and in the absence of protein/energy malnutrition.

• 出版日期2014