Anti-Allergic Properties of a Matured Fruit Extract of the Date Palm Tree (Phoenix dactylifera L.) in Mite-Sensitized Mice

作者：Karasawa Koji; Otani Hajime^*

来源：Journal of Nutritional Science and Vitaminology, 2012, 58(4): 272-277.

DOI：10.3177/jnsv.58.272

• anti-allergic property
• date polyphenol
• Th1/Th2 balance
• IgE-producing plasma cell
• mast cell

The effects of oral ingestion of a hot water extract of matured fruit of the date palm tree (Phoenix dactylifera L.) on allergic responses were investigated in mite-sensitized mice. Sneezing and nose rubbing events in mice given a date extract-added diet were significantly lower than in those given an extract-free (control) diet. The serum total and mite antigen-specific immunoglobulin (Ig) E levels, and the number of spleen interleukin-4(+)CD4(+), IgE(+)B220(+) and Fc epsilon RI alpha(+)CD117(+) cells was significantly lower in mice given the date extract- added diet than in those given the control diet. Chlorogenic acid, pelargonin and ferulic acid significantly reduced the number of IgE(+)B220(+) cells, while chlorogenic acid and pelargonin significantly decreased the number of Fc epsilon RI alpha(+)CD117(+) cells in mouse spleen cell cultures. These results suggest that some polyphenols in the date may reduce mite-induced allergic symptoms in mice via a decrease in the number of IgE-producing plasma cells and high-affinity IgE receptor-expressing mast cells.

• 出版日期2012-8