alpha-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice

作者：Kim Gun Dong; Kim Tae Ho; Jang An Hee; Ahn Hyun Jong; Park Yong Seek; Park Cheung Seog^*

来源：Experimental Dermatology, 2011, 20(2): 97-101.

DOI：10.1111/j.1600-0625.2010.01165.x

• 2-4-dinitrofluorobenzene
• atopic dermatitis
• CD4+T cells
• NC
• Nga
• alpha-Lipoic acid

Atopic dermatitis (AD) is a common skin disease that has complex pathogenic mechanisms. Under specific pathogen-free conditions, repeated epicutaneous treatment of 2-4-dinitrofluorobenzene (DNFB) evokes AD-like clinical symptoms in NC/Nga mice. alpha-Lipoic acid (alpha-LA; 1, 2-dithiolane-3-pentanoic acid) is a dietary component that is synthesized in bacteria, yeast, plants, and mammals. alpha-LA and its reduced form, dihydrolipoic acid, are powerful antioxidants that have many physiological functions, including free radical scavenging of reactive oxygen species, generation of cellular antioxidants, chelation of metal ions, and inflammatory suppression. In this study, we investigated whether alpha-LA suppresses AD-like skin lesions induced by repeated DNFB application in NC/Nga mice. alpha-LA significantly suppressed production of interferon (IFN)-gamma and interleukin (IL)-4 by activated CD4+ T cells. We found that the oral administration of alpha-LA reduced AD-like clinical symptoms and inhibited increases of epidermal thickness in DNFB-induced AD-like skin lesions of NC/Nga mice. Furthermore, total serum IgE levels were dramatically reduced by topical alpha-LA treatment. Our findings suggest that oral administration of alpha-LA suppresses the development of AD in DNFB-treated NC/Nga mice and reduces IFN-gamma and IL-4 production from activated CD4+ T cells as well as total serum IgE levels.

• 出版日期2011-2