Derivatization of a tris-oxazole using Pd-catalyzed coupling reactions of a 5-bromooxazole moiety

作者：Shibata Kazuaki; Yoshida Masahito; Doi Takayuki^*; Takahashi Takashi

来源：Tetrahedron Letters, 2010, 51(13): 1674-1677.

DOI：10.1016/j.tetlet.2010.01.064

• Oxazoles
• Pd-catalyzed reaction
• Amination
• Alkoxylation
• Cross-coupling

Modification at the C5 position of an oxazole ring contained in a 2,4-concatenated tris-oxazole by Pd-catalyzed coupling reactions was performed. Novel Pd-catalyzed amination and alkoxylation of a 5-bromooxazole derivative as well as Suzuki-Miyaura coupling and Migita-Stille coupling have been demonstrated. A wide variety of functional groups, including aryl, heteroaryl, primary and secondary amines, and phenol, were introduced in the 5-bromooxazole moiety in moderate to excellent yields using Pd(OAc)(2)/S-PHOS or Pd(OAc)(2)/X-PHOS as a catalyst.

• 出版日期2010-3-31