The Perioperative von Willebrand Factor Activity and Factor VIII Levels Among Alcohol Use Disorder Patients Undergoing Total Knee or Hip Replacement

作者：Schoenfeld Helge^*; Perka Carsten; Ziemer Sabine; Huebner Ranja; Schink Tania; Neuner Bruno; Spies Claudia

来源：Substance Use & Misuse, 2010, 45(7-8): 1216-1229.

DOI：10.3109/10826081003688906

• factor VIII
• von Willebrand factor
• alcohol use disorder
• knee replacement
• hip replacement
• bleeding complication
• public health
• hazardous alcohol consumption

Alcohol use disorder patients have a five-fold higher risk of postoperative bleeding complications. We measured the perioperative von Willebrand factor and factor VIII levels in consecutive patients with alcohol use disorder. In one university hospital, 105 patients scheduled for arthroplasty were screened, and 25 fulfilled inclusion criteria. Postoperatively, we found significantly decreased von Willebrand factor ristocetin cofactor values over time among alcohol use disorder patients and significantly different time courses of factor VIII levels between patients with and without a diagnosed alcohol use disorder. Blood loss was significantly increased among alcohol use disorder patients on their first postoperative day.</.

• 出版日期2010-6