A New Compound with Anti-oxidative Activity from Seeds of Jatropha curcas

作者：LI Ling WANG Xin luan LI Xiao fan WANG Nai li College of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang China Key Laboratory for New Drugs Research of Traditional Chinese Medicine in Shenzhen Research Institute of Tsinghua University in Shenzhen Shenzhen China

来源：Chinese Herbal Medicines, 2010, (04): 245-247.

• anti-oxidative activity
• DPPH
• jatrophasin A
• resveratrol
• seeds of Jatropha curcas

Objective To search for chemical constituents with anti-oxidative activity from seeds of Jatropha curcas. Methods DPPH radical scavenging assay was used to screen fractions or constituents with anti-oxidative activities. Active fractions were separated by varied chromatography and then identified on the basis of physiochemical properties and spectroscopic methods. Results The n-butanol layer of ethanol extract from the seeds of J. curcas showed stronger activity than other fractions and was studied further. A new compound was isolated from this active layer, and its structure was identified as jatrophasin A (3,4,4′,5′-tetrahydroxyl-3′-methoxyl-bisepoxylignan, 1). It showed stronger anti-oxidative activity compared with resveratrol. Conclusion Compound 1 is a new compound which has never been reported with strong anti-oxidative activity.

• 出版日期2010-11-20