Association between monoamine oxidase gene polymorphisms and smoking behavior: A meta-analysis

作者：Yang Xiaorong; Chen Hui; Li Suyun; Wang Qiang; Pan Lulu; Jia Chongqi^*

来源：Drug and Alcohol Dependence, 2015, 153: 350-354.

DOI：10.1016/j.drugalcdep.2015.05.024

• Monoamine oxidase gene
• Smoking behavior
• Polymorphism
• Meta-analysis
• MAO-A
• MAO-B

Background: A number of studies have researched the association between monoamine oxidase gene (MAO) polymorphisms and smoking behavior, but the conclusion is quite inconsistent. A meta-analysis was conducted to assess the association of MAO-A C1460T, MAO-A VNTR and MAO-B G644A polymorphisms with smoking behavior.
Methods: A comprehensive search was performed to identify all eligible studies. Meta-analysis was applied to calculate the pooled effect values and their 95% confidence intervals. Meta-regression and the 'leave one out' sensitivity analysis were used to explore potential sources of heterogeneity. The risk of bias was assessed by the Egger regression asymmetry test.
Results: 11 articles conformed to the inclusion criteria. The meta-analysis showed T allele in MAO-A C1460T reduced the risk of heavy smoking (OR= 0.66, 95% CI: 0.52-0.84; I-2= 0.0%), especially in Caucasians; the active group in MAO-A VNTR increased the likelihood of failed smoking cessation in males (OR= 1.49, 95% CI: 1.01-2.22; I-2 = 0.0%); A allele in MAO-B G644A reduced the risk of heavy smoking in males (OR= 0.20, 95% Cl: 0.04-0.98).
Conclusion: Our findings indicate that the low activity of monoamine oxidase gene polymorphisms has a protective effect on smoking cessation and heaviness. Some associations and applications should be further confirmed.

• 出版日期2015-8-1
• 单位山东大学