Differences in Disease Presentation, Treatment Outcomes, and Toxicities in African American Patients Treated With Radiation Therapy for Prostate Cancer

作者：Shah Chirag; Jones Pamela M; Wallace Michelle; Kestin Larry L; Ghilezan Mihai; Fakhouri Monty; Jaiyesimi Ishmael; Ye Hong; Martinez Alvaro; Vicini Frank^*

来源：American Journal of Clinical Oncology: Cancer Clinical Trials , 2012, 35(6): 566-571.

DOI：10.1097/COC.0b013e3182208262

• prostate cancer
• radiation therapy
• African American
• health care disparities

Objectives: We analyzed differences in disease presentation, outcomes, and toxicities between African American (AA) and White (W) men treated with definitive radiation therapy for their prostate cancer. %26lt;br%26gt;Methods: Three thousand one hundred eighty cases of prostate cancer treated with various radiation modalities at a single institution were reviewed. The cohort consisted of 92% W patients and 8% AA patients. Clinical and pathologic characteristics at presentation, treatment outcomes, and related toxicities were analyzed between the 2 groups. The median follow-up was 6.6 years (0.6 to 22.4 y). %26lt;br%26gt;Results: At presentation, AA men were younger (P %26lt; 0.001) and more likely to have a Gleason score of %26gt;= 7 (47.9% vs. 39.2%, P = 0.006). No difference in the 5 or 10-year rates of biochemical failure, disease-free survival, or distant metastases were noted. Although there was a trend for improved 10-year overall survival for AA men (65.3% vs. 57.4%, P = 0.06), cause-specific survival was significantly improved at 10 years (98.6% vs. 90.6%, P = 0.002). Similar findings were seen when controlling for radiation therapy dose, the use of hormonal therapy, and modality of radiation therapy used. Overall, genitourinary/gastrointestinal toxicities were similar regardless of the modality used. %26lt;br%26gt;Conclusions: Despite differences in presenting characteristics, AA men did not have inferior clinical outcomes but rather improved cause-specific survival when treated with standard of care radiation therapy. Regardless of the treatment modality used, toxicities between AA and W men were comparable.

• 出版日期2012-12