A novel type of matrix for surface-assisted laser desorption-ionization mass spectrometric detection of biomolecules using metal-organic frameworks

作者：Fu Chien Ping; Lirio Stephen; Liu Wan Ling; Lin Chia Her^*; Huang Hsi Ya

来源：Analytica Chimica Acta, 2015, 888: 103-109.

DOI：10.1016/j.aca.2015.07.029

• Metal-organic frameworks
• Biomolecules
• Carbohydrates
• Peptides
• Surface-assisted laser desorption-ionization mass spectrometry

A 3D metal-organic framework (MOF) nanomaterial as matrix for surface-assisted laser desorption/ ionization mass spectrometry (SALDI-MS) and tandem mass spectrometry (MS/MS) was developed for the analysis of complex biomolecules. Unlike other nanoparticle matrices, this MOF nanomaterial does not need chemical modification prior to use. An exceptional signal reproducibility as well as very low background interferences in analyzing mono-/di-saccharides, peptides and complex starch digests demonstrate its high potential for biomolecule assays, especially for small molecules.

• 出版日期2015-8-12