Association of Adiponectin gene polymorphisms and nonalcoholic fatty liver disease

作者：Li, Hong-Jue; Li, Chang-Ping^*; Zhang, Chao; Zhong, Xiao-Lin; Shi, Lei

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(9): 16676-16681.

• Adiponectin
• gene polymorphism
• NAFLD

Objective: To investigate the correlation between Adiponectin gene polymorphisms and the genetic susceptibility of nonalcoholic fatty liver disease (NAFLD). Methods: 357 NAFLD patients from January 2005 to December 2013 and 357 cases of healthy controls among the Han population were collected; polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect three tagSNPs (Rs2241767, rsl501299 and rs3774261) of Adiponectin. Risk factors were analyzed by multivariate logistic regression and haplotype analysis was performed using SHEsis software. Results: Rs2241767, rsl501299 and rs3774261 polymorphisms were associated with the risk of NAFLD. Haplotype analysis showed that, A-T-A haplotype was a protective factor of NAFLD (OR: 0.154, 95% CI: 0.011-0.576, P = 0.004) and G-G-A (OR: 4.012, 95% CI: 2.118-10.324, P < 0.001) and G-T-G (OR: 5.219, 95% CI: 2.751-12.651, P < 0.001) haplotype was risk factors of NAFLD. Conclusion: There was an association between Adiponectin gene polymorphisms and the genetic susceptibility of NAFLD.

• 出版日期2015
• 单位上海交通大学; 西南医科大学