Aborted Cardiac Arrest in a Patient Carrying KCNE1 D85N Variant during the Postpartum Period

作者：Nakajima Tadashi^*; Kaneko Yoshiaki; Manita Mamoru; Iso Tatsuya; Kurabayashi Masahiko

来源：Internal Medicine, 2010, 49(17): 1875-1878.

DOI：10.2169/internalmedicine.49.3859

• long QT syndrome
• ventricular tachyarrhythmias
• postpartum period
• KCNE1

The postpartum period is associated with an increased risk of fatal ventricular tachyarrhythmias in patients with congenital long QT syndrome (LQTS). We describe a 20-year-old female with LQTS who experienced aborted cardiac arrest during the postpartum period. Genetic screening identified a KCNE1 D85N variant, which has been reported to be a LQTS-causing gene variant, in the patient and her younger sister, whose QT interval was also prolonged. Since the allele frequency of this variant is almost 1%, it may be important to clarify whether such variant carriers indeed have an increased risk of fatal ventricular tachyarrhythmias during the postpartum period.

• 出版日期2010