Antioxidative Constituents from the Whole Plant of Actinostemma lobatum Maxim

作者：Kim Dae Keun^*

来源：Journal of the Korean Society for Applied Biological Chemistry, 2010, 53(6): 746-751.

DOI：10.3839/jksabc.2010.113

• Cucurbitaceae
• DPPH
• superoxide quenching activity

As part of an ongoing search for natural plants with antioxidant compounds by measuring the radical-scavenging effect on DPPH (1,1-diphenyl- 2-picrylhydrazyl), a total extract of the whole plant of Actinostemma lobatum (Cucurbitaceae) was found to show potent antioxidant activity. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of eight compounds: actinostemmoside C (1), kaempferol-3-O-alpha-L-rhamnopyranosyl (1 -> 6)-beta-D-glucopyranoside (2), quercetin-3-O-beta-L-rhamnopyranosyl (1 -> 6)-beta-D-glucopyranoside (3), quercetin-3-O-beta-D-glucopyranoside (4), kaempferol (5), quercetin (6), lobatoside C (7), and lobatoside B (8). Their structures were elucidated using spectroscopic studies. Compounds 2, 4, 5, and 6 were isolated for the first time from this plant. Compounds 2-4 and 6 showed significant antioxidative effects during the DPPH-free radical-scavenging test and the superoxide quenching activity test.

• 出版日期2010-12