Midazolam as a first-line treatment for neonatal seizures: Retrospective study

作者：Dao Kim; Giannoni Eric; Diezi Manuel; Roulet Perez Eliane; Lebon Sebastien^*

来源：Pediatrics International, 2018, 60(5): 498-500.

DOI：10.1111/ped.13554

• anticonvulsant
• infant
• midazolam
• neonatal seizure
• phenobarbital

Midazolam is commonly used to treat refractory seizures in newborns and as a first-line anti-epileptic drug in children. Its use as first-line treatment of neonatal seizures has not been investigated so far. We retrospectively studied the tolerability of midazolam in 72 newborn infants who received i.v. or i.n. midazolam as first-line treatment for seizures. No major side-effect exclusively due to midazolam was reported. The i.n. route was used for 20 patients (27.8%). Effectiveness could not be formally evaluated due to the absence of systematic electroencephalogram recording while midazolam was administered. In conclusion, midazolam was well-tolerated as a first-line abortive emergency treatment of neonatal seizure. The i.n. route offers a useful alternative to i.v. phenobarbital or phenytoin in emergency settings.

• 出版日期2018-5