An efficient one-pot synthesis of 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione from 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione by two annulation reactions

作者：Jia Ping; Wu Xuling; Yu Yongping; Zhang Guolin^*

来源：Steroids, 2009, 74(2): 229-232.

DOI：10.1016/j.steroids.2008.10.018

• Ring closure
• Nickel
• Cyclizations
• Epoxidations

An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5,9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The absolute configuration was also confirmed by X-ray crystal analysis.

• 出版日期2009-2
• 单位浙江大学