The Distribution of Congenital Anomalies Within the VACTERL Association Among Tumor Necrosis Factor Antagonist-exposed Pregnancies Is Similar to the General Population

作者：Crijns Hubertina J M J; Jentink Janneke; Garne Ester; Gispen de Wied Christine C; Straus Sabine M J M; de Jong van den Berg Lolkje T W^*

来源：Journal of Rheumatology, 2011, 38(9): 1871-1874.

DOI：10.3899/jrheum.101316

• VACTERL ASSOCIATION
• EUROCAT
• TUMOR NECROSIS FACTOR ANTAGONISTS
• BIRTH DEFECT
• SAFETY

Objective. To compare the distribution of congenital anomalies within the VACTERL association (vertebral defects, anal atresia, cardiac, tracheoesophageal, renal, and limb abnormalities) between patients exposed to tumor necrosis factor-alpha (TNF-alpha) antagonist and the general population.
Methods. Analysis for comparison of proportional differences to a previous publication between anomaly subgroups, according to subgroup definitions of the European Surveillance of Congenital Anomalies (EUROCAT), a population-based database.
Results. Most EUROCAT subgroups belonging to the VACTERL association contained only one or 2 records of TNF-a antagonist exposure, so comparison of proportions was imprecise. Only the category "limb abnormalities" showed a significantly higher proportion in the general population.
Conclusion. The high number of congenital anomalies belonging to the VACTERL association from a report of pregnancies exposed to TNF-alpha antagonists could not be confirmed using a population-based congenital anomaly database. (First Release July 1 2011; J Rheumatol 2011;38:1871-4; doi:10.3899/jrheum.101316)

• 出版日期2011-9