Age of Infection with Kaposi Sarcoma-Associated Herpesvirus and Subsequent Antibody Values Among Children in Uganda

作者：Nalwoga Angela; Miley Wendell; Labo Nazzarena; Elliott Alison; Cose Stephen; Whitby Denise; Newton Robert

来源：Pediatric Infectious Disease Journal, 2018, 37(8): E225-E228.

DOI：10.1097/INF.0000000000001909

• Kaposi sarcoma-associated herpesvirus
• seroconversion age
• antibody values
• Uganda

We investigated associations between Kaposi sarcoma-associated herpesvirus (KSHV) seroconversion age and KSHV antibody values in Ugandan children. Every annual delay in KSHV seroconversion age was associated with a reduction of 19% (P < 0.0001) in K8.1 and 27% (P < 0.0001) in ORF73 antibody values at 6 years of age. Early infection may be an important risk factor for KSHV pathogenesis and viral shedding in saliva, leading to transmission.

• 出版日期2018-8