Non-Bacterial Osteitis as Autoinflammatory Disease: Manifestations from Symptoms to Syndrome

作者：Jansson A F^*

来源：Aktuelle Rheumatologie, 2011, 36(4): 252-260.

DOI：10.1055/s-0031-1275659

• osteitis
• CRMO
• SAPHO
• inflammation

Non-bacterial osteitis (NBO) can be observed as a single symptom of disease or may be associated with other inflammatory conditions, mainly of the skin and/or bone. The variability of clinical presentations seems comparable to rheumatic arthritis. Meanwhile sterile osteitis was described as a feature of genetically defined inflammatory syndromes with manifestations in very early childhood. These are defined as autoinflammatory diseases. Recurrent episodes triggered by innate immune mechanisms, in the absence of specific autoantibodies and without exogeneous triggers, are criteria for this classification. Non-syndromal non-bacterial inflammatory bone lesions are neither pathophysiologically nor genetically well defined. With the help of the current literature on this unexplored field and on the basis of our own clinical and laboratory findings, it can be shown that also NBO without syndromal features may be classified as auto-inflammatory disorders. Different clinical presentations are highlighted in view of inflammation parameters and genetic findings - as far as available. The current impetus and vast new findings in this field pose again and again the question whether auto-immunity and auto-inflammation need to be separated from each other. Whether or not NBO and/or other rheumatic diseases will have to be (re) classified remains an exciting topic. Therefore, in the near future, so far non-defined disorders may be diagnosed as rheumatic-inflammatory conditions.

• 出版日期2011-8