Structure and cytotoxicity of steroidal glycosides from Allium schoenoprasum

作者：Timite Gaoussou; Mitaine Offer Anne Claire; Miyamoto Tomofumi; Tanaka Chiaki; Mirjolet Jean Francois; Duchamp Olivier; Lacaille Dubois Marie Aleth^*

来源：Phytochemistry, 2013, 88: 61-66.

DOI：10.1016/j.phytochem.2012.12.001

• Allium schoenoprasum
• Amaryllidaceae
• Steroidal saponins
• 2D NMR
• Cytotoxicity

A phytochemical analysis of the whole plant of Allium schoenoprasum, has led to the isolation of four spirostane-type glycosides (1-4), and four known steroidal saponins. Their structures were elucidated mainly by 2D NMR spectroscopic analysis and mass spectrometry as (20S,25S)-spirost-5-en-3 beta,12 beta,21-triol 3-O-alpha-L-rhamnopyranosyl-(1 -%26gt; 2)-beta-D-glucopyranoside (1), (20S,25S)-spirost-5-en-3 beta,11 alpha,21-triol 3-O-alpha-L-rhamnopyranosyl-(1 -%26gt; 2)-beta-D-glucopyranoside (2), laxogenin 3-O-alpha-L-rhamnopyranosyl-(1 -%26gt; 2)-[beta-D-glucopyranosyl-(1 -%26gt; 4)]-beta-D-glucopyranoside (3), and (25R)-5 alpha-spirostan-3 beta,11 alpha-diol 3-O-beta-D-glucopyranosyl-(1 -%26gt; 3)-[beta-D-glucopyranosyl-(1 -%26gt; 4)]-beta-D-galactopyranoside (4). Four of the isolated compounds were tested for cytotoxic activity against the HCT 116 and HT-29 human colon cancer cell lines.

• 出版日期2013-4