Dual effects of sodium aescinate on vascular tension in rat thoracic aorta

作者：Li, Xia; Chen, Guo-Ping; Li, Liang; Wang, Kai-Jun; Zhang, Bi-Qi; Hu, Shen-Jiang^*

来源：Microvascular Research, 2010, 79(1): 63-69.

DOI：10.1016/j.mvr.2009.11.002

• Sodium aescinate
• Thoracic aorta
• Vasoconstriction
• Vasorelaxation
• Vasomotion

Objective: Sodium aescinate (SA) is used as a vasoactive drug in clinical treatment. This study was designed to investigate the effects of SA on rat isolated thoracic aorta and the possible mechanisms. @@@ Methods: Isometric tension was recorded in response to drugs in organ bath. @@@ Results: The effects of SA obeyed an all-or-nothing response. SA in relatively low dose (>= 50 mu g/ml) had an endothelium-independent contractile effect in rat aorta (P<0.01), which depended on extracellular Ca2+ influx via L-type Ca2+ channel (P<0.05). SA in relatively high dose (>= 100 mu g/ml) also induced vasoconstriction in Ca2+-free medium (P<0.01), which was independent of the activity of inositol-1,4,5-trisphosphate receptor (IP3R), ryanodine receptor (RYR). and protein kinase C (PKC). SA in relatively high dose (>= 100 mu g/ml) dilated both endothelium-intact and endothelium-denuded aortic rings precontracted by phenylephrine (PE) or KCl (each P<0.01). SA inhibited extracellular Ca2+ influx induced by PE or KCl (each P<0.01) and had no activation effect on K+ channels on vascular smooth muscle. The relaxant effect of SA partly depended on the activity of NO synthase but not on the activity of cyclooxygenase. @@@ Conclusions: Taken together, this study indicated that SA had dual effects on vascular tension in rat isolated thoracic aorta.

• 出版日期2010-1
• 单位浙江大学