科研之友
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摘要
Asymmetric conjugate addition of bromonitromethane to alpha,beta-unsaturated ketones was studied using a series of chiral primary amines as the catalysts. The cascade intramolecular cyclopropanation provided nitrocyclopropanes efficiently. Excellent enantioselctivities and good yields were obtained for several cyclic enones catalyzed by a bifunctional thiourea-primary amine. Both acid and base additives were found to be necessary for the transformation.
- 出版日期2010-1
- 单位中山大学
