科研之友
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摘要
Casein kinase 1 alpha (CK1 alpha) is a member of serine/threonine protein kinases, which expressed in all kinds of eukaryotes, and the sequence structure is highly conserved. In mammals, CK1 alpha is involved in a variety of cellular physiological processes and partial signaling pathways. It has been shown that CK1 alpha acts as a tumor suppressor and it is closely related to the occurrence and development of tumor. However, little is known about its role in esophageal squamous cell carcinoma (ESCC). Purpose: The aim of present study was to explore the role and the prognostic significance of CK1 alpha expression in ESCC. Methods: The expression of CK1 alpha was detected by immunohistochemistry (IHC) technique in 100 cases of ESCC and their corresponding adjacent nonneoplastic esophageal tissues (n=80), and analyzed the relationship between CK1 alpha expression and clinicopathological parameters, survival rate and prognosis of ESCC patients. Results: The positive percentage of CK1 alpha protein in ESCC was 56% (56/100), which was significantly lower than that in nonneoplastic esophageal tissues was 90% (72/80), (X-2=25.010, P=0.000). The expression of CK1 alpha was significantly related with differentiation degree, but not with the sex, age, tumor size, depth of invasion, lymphatic invasion and AJCC clinical stage. On the basis of univariate and multivariate Cox regression analysis, we found that tumor size and depth of invasion were independent risk factors for worse prognosis in ESCC patients. Furthermore, survival analysis date revealed that the positive expression of CK1 alpha had significantly better survival than the negative expression of CK1 alpha in ESCC patients after curative surgery. Conclusion: CK1 alpha may play an important role in the carcinogenesis and development of ESCC and might provide clinically useful prognostic information in cases of ESCC.
- 出版日期2016
- 单位长治医学院; 山西医科大学
