ERCP in infants, children and adolescents is feasible and safe: results from a tertiary care center

作者：Felux Jasmin; Sturm Ekkehard; Busch Andreas; Zerabruck Emanuel; Graepler Florian; Stueker Dietmar; Manger Andreas; Kirschner Hans Joachim; Blumenstock Gunnar; Malek Nisar P; Goetz Martin^*

来源：United European Gastroenterology Journal, 2017, 5(7): 1024-1029.

DOI：10.1177/2050640616687868

• Endoscopic retrograde cholangiopancreatography
• biliary atresia
• pediatric endoscopy
• cannulation
• Kasai procedure
• post-ERCP pancreatitis

Background: Indications for endoscopic retrograde cholangiopancreatography (ERCP) in children differ from adults. Paucity of data and concerns about potential lower effectiveness and more side effects limit its use even in high volume centers. We retrospectively analyzed indications, success rates, limitations, and side effects of ERCPs in children <18 years.
Methods: From January 2012 to March 2015, 54 ERCPs were performed in 31 children (median age 11 (0-17) years; median weight 22 (3.3-142.7) kg) with suspected choledocholithiasis (n=13 interventions in 9 patients), post-transplantation anastomotic stenosis (10/4), malignancy (10/5), chronic pancreatitis (7/1), biliary atresia (6/6), anomaly (2/2), leak (4/3), or primary sclerosing cholangitis (PSC) (2/1). All patients were followed up as inpatients.
Results: Thirty-six therapeutic and 18 diagnostic procedures were performed by adult ERCP expert endoscopists. Successful intervention was achieved in 90.7% of cases. Failed cannulation (n=4) was associated with lower body weight (p=0.023). In children younger than 1 year, ERCP was significantly more often diagnostic than in patients >1 year (p<0.001). In three of six infants with suspected atresia, surgical exploration was avoided. Five complications were recorded (9.3%), and included four episodes of mild pancreatitis (7.4% post-ERCP pancreatitis (PEP) rate) and one cholangitis in PSC. A trend towards a protective effect of pancreatic stents on PEP was observed. All complications were managed conservatively. No complications were attributed to mechanical stress on the gastrointestinal tract.
Conclusions: ERCP in newborns, infants, and adolescents can be safely performed with high technical and clinical success. Endoscopists must be aware of differing spectrum of pediatric diseases. Failed cannulation was associated with lower body weight of young children. Complications were similar to rates reported in adults.

• 出版日期2017-11